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Mesothelioma and Other Asbestos Related Cancers

People who have a history of exposure to asbestos are at risk of developing various types of cancer that include mesothelioma. These cancers have a long latency period, meaning symptoms do not manifest for many years after exposure.

The risk of developing pleural and peritoneal mesothelioma declines with time since the first exposure. The evidence is drawn from six cohort studies in occupational settings and two residential cohorts that have long-term follow-up.

What is Mesothelioma?

Mesothelioma is cancer of the inner organs' linings that include the lung (pleural mesothelioma) and abdomen (peritoneal mesothelioma) or the heart (pericardial mesothelioma). It is a rare, aggressive disease that usually begins in the lining in the chest cavity. However, it could also affect the lining in the stomach and other areas of your body. Asbestos exposure is the main cause of mesothelioma, and the cancer usually doesn't develop until a long time after the initial exposure.

Those who are exposed to asbestos in the workplace have a greater chance of developing cancer than others. Asbestos fibres can be swallowed or inhaled and adhere to the lining of the organ. The irritate the lining which causes abnormal cells to grow and form tumors. The symptoms usually do not show until a person has developed advanced mesothelioma.

Asbestos exposure most often occurs in industrial jobs in which workers handled the material or were in close proximity to it. Asbestos is utilized in a variety of trades, including construction, shipbuilding and auto repair. Veterans who were in the military are at a higher risk for mesothelioma, as asbestos was widely used on bases and ships.

People who have a history of asbestos exposure need to undergo regular checks and be aware of any unusual symptoms. If a doctor suspects mesothelioma, they may request imaging tests such as CT scans, MRI or PET scans to check for tumors and determine whether they've developed. They can also inquire about the patient's history of asbestos exposure and carry out an examination. Some cases of mesothelioma are associated with genetic changes, and therefore some patients might benefit from genetic tests.

Risk Factors

The main risk factor for mesothelioma is exposure to asbestos. Asbestos is a mineral that is made up of tiny fibers that are tough and withstand heat. Asbestos used to be used in many manufacturing and construction products, including insulation, brakes and shingles. When asbestos is disturbed, it releases dust that could be inhaled or swallowed. As time passes, this could cause irritation of the mesothelium which can ultimately develop into mesothelioma.

People who have an history of occupational asbestos exposure are at the greatest risk for mesothelioma. This includes people who worked in industries such as mining, shipbuilding, construction and automotive repair. Veterans of the military are also at risk because many branches of the military used asbestos law-based material.

Other factors that increase the risk of mesothelioma is a family history of asbestos exposure as well as prior treatment with radiation to the chest. In addition, the type of mesothelioma that is diagnosed has an impact on the risk. Pleural mesothelioma, the most frequent type and usually affects the lung. Other forms of mesothelioma are testicular, pericardial, and peritoneal.

In general, the risk of mesothelioma increases with the third or fourth power of latency - which is the length of time it takes a person to get diagnosed. However, the rate of pleural mesothelioma has an apparent flattening after approximately 40 years of exposure. Peritoneal and pericardial mesothelioma both show this trend as well. Those who have para-occupational exposure to asbestos legal, like living close to an asbestos plant, or consuming products from the household that are contaminated are also at a higher risk of developing mesothelioma. One study of six cities showed that those with this kind of exposure were at a higher mesothelioma danger than those with only occupational exposure.

Signs and symptoms

Malignant mesothelioma affects the cellular of the organs' linings. Most often, it is found in the lung lining and abdomen. Mesothelioma can also develop in the lining around the heart or testicles. It is a rare form of cancer and the majority of patients diagnosed with mesothelioma have worked in positions that exposed them to asbestos. It can take a long time for symptoms of mesothelioma to develop, and the disease is not curable.

Asbestos is a group of minerals with thin microscopically-sized fibers that are resistant to heat, chemicals, and fire. It was once widely used in construction, shipbuilding, manufacturing and many other industries. Exposure to asbestos can cause mesothelioma because the fibers get stuck in tissues that line organs and protect them, causing irritation and damaging cells. This can cause tumors to start growing and eventually becoming cancerous.

The most commonly encountered type of mesothelioma is pleural mesothelioma, which develops in the lining of the lungs (pleura). It can also start in the abdomen's lining (peritoneum) or within the membrane that surrounds the heart or testicles. Mesothelioma can also spread to lymph nodes, causing swelling of the lymph nodes.

The majority of people diagnosed with mesothelioma have many years of exposure to asbestos attorney and are suffering from other ailments such as chronic lung disease. Symptoms of mesothelioma can be similar to other conditions and it is therefore important to visit a doctor if you are experiencing persistent or worrying signs and symptoms. Doctors will inquire about your previous exposure to asbestos and may also conduct a physical examination. They can also order scans of your body or blood tests of your chest and abdomen. These tests can detect any fluid or thickening between the lungs and chest wall.

Diagnosis

When asbestos fibers become stuck to the body, they could cause damage and may develop into cancerous tumors. Different types of asbestos-related cancers form in various organs or tissues, and each type can be diagnosed with different tests. Mesothelioma develops in the tissues of the chest cavity and lungs (pleura) and stomach membranes (peritoneum) or around the reproductive organs and the heart.

The first step to diagnose mesothelioma is for a patient to talk to his or her doctor about their history of asbestos exposure and the symptoms they have been experiencing. Doctors also conduct a physical examination and order basic tests like blood tests to determine how well the lungs are functioning.

X-rays or CT scans can help doctors see the affected area better. In some cases doctors will perform a pleural effusion test to determine if mesothelioma, or another disease is causing fluid buildup in the lungs. The pleural effusion could be a sign of pleural mesothelioma, peritoneal mesothelioma or a less common form of mesothelioma called biphasic or mixed mesothelioma.

Mesothelioma is often misdiagnosed due to the symptoms are similar to those of other diseases and conditions. The most frequent symptoms are difficulty breathing and chest pain. Pleural mesothelioma can also cause a cough, chest tightness and fatigue. Peritoneal mesothelioma can cause abdominal discomfort swelling, distension and pain. Testicular mesothelioma may manifest as a swollen or itchy lump that is located in the testicles.

Researchers are studying certain blood-borne proteins in hopes of developing an approach to detect mesothelioma earlier in its development. They are also studying several other tests and procedures that can improve diagnostic accuracy, including mesothelioma scans and MRIs. They are also researching genetic mutations and how to determine if a person is at risk for mesothelioma by examining their family history.

Treatment

Asbestos exposure is a major risk factor for mesothelioma. People who have worked with asbestos in the past, specifically for prolonged periods of time or in high risk jobs such as construction, electrical work, shipbuilding, auto repair and military service are at a higher risk.

Exposure to asbestos triggers mesothelioma when fibers get stuck in the tissue that lines and protects vital organs. The mesothelium is irritated by the asbestos fibers and cause DNA damage, which leads to cancerous cells. Mesothelioma symptoms usually are not evident until years after exposure.

Symptoms differ depending on the type of mesothelioma and where it develops within the body. Most mesothelioma cases involve the lining of the lungs (pleural mesothelioma) however, it can be found in the stomach's lining (peritoneal mesothelioma) and the heart (pericardial mesothelioma) or testicles (testicular mesothelioma).

Mesothelioma staging helps doctors determine treatment options. The cancer is classified as stage I to stage IV, with stages I and II being the earliest and the most manageable. Stage III and IV are the later stages of cancer that are more difficult to treat, however there are still many treatment options available.

Pleural mesothelioma, the most common form of the disease that affects the lining of the lungs and chest wall, as well as the abdomen. In most cases of pleural mesothelioma asbestos exposure happened in the workplace. This is most likely because of breathing in asbestos particles from the air or ingestion of the cancerous substance through the food chain.

Other risk factors include a family history of mesothelioma or genetic mutations as well as previous radiation therapy for a different condition. If you were exposed to asbestos and suffer from mesothelioma symptoms, it is important to see a doctor. You may also benefit from genetic counseling. In certain instances, a mesothelioma specialist can assist you in filing an action against companies that wrongfully put asbestos in everyday products.
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